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It led to the arrest or report of seven men from suburbs in Adelaide's north and north-west, with three men alleged to be senior members of the Descendants bikie gang.
Police seized about $145,000 in cash, as well as 2,000 ecstasy pills, 21 marijuana plants, 168 grams of methamphetamine, steroids, cocaine, the drug Fantasy, three batons and eight firearms with ammunition.
Police also seized cars, motorcycles and a fishing boat, alleging they had been bought with the proceeds of crime.
Detective Superintendent Craig Patterson said the investigation was ongoing.
"Members of outlaw motorcycle gangs may believe they can operate outside the law, [but] they cannot," he said.
"We will continue to target organised criminal syndicates to ensure the safety of the community."
A 26-year-old man from Salisbury Heights was charged with numerous drug tracking, supply and commercial possession charges.
He was refused bail and is due to appear in the Elizabeth Magistrates Court on Friday.
A 31-year-old man from Brahma Lodge was charged with supplying drugs as well as resisting and hindering police. He was refused bail and is due to appear in the Adelaide Magistrates Court on Friday.
A 27-year-old-man from Salisbury Heights was arrested for drug trafficking. He was bailed to appear in the Adelaide Magistrates Court later this month.
Another four men were reported.
This included a 65-year-old Brahma Lodge man for cultivating cannabis and possessing prescribed equipment, a 26-year-old man from Prospect for possessing prescribed medication, a 30-year-old man from Parafield Gardens for possessing dangerous articles, and a 24-year-old man from Seaton for possessing prescribed equipment.
Police said the reported men would be summoned to court at a later date.